PURE study: Fat is okay, carbohydrates in excess bad.

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study.

The Lancet. November 04 2017.

  • High carbohydrate intake (>60% of energy) was associated with an adverse impact on total mortality and non-cardiovascular disease mortality

  • Higher fat intake (including saturated and unsaturated fatty acids), however, was associated with lower risk of total mortality, non-cardiovascular disease mortality and stroke

Investigations are important and clinical skills are fallible.

“The addition of ultrasonography and laboratory tests increased rheumatologists’ diagnostic accuracy for RA from 27 to 70%.”

“Experienced rheumatologists, if deprived of information on prior external imaging and laboratory workup by blinding, were not able to correctly classify the majority of patients presenting with polyarthralgia or arthritis symptoms for inpatient workup, relying only on a brief symptom-focused medical history and physical examination.”

The ability of rheumatologists blinded to prior workup to diagnose rheumatoid arthritis only by clinical assessment: a cross-sectional study.” Article in Rheumatology, Volume 57, Issue 9, 1 September 2018.